6. CARCINOGENICITY OF TCDD IN ANIMALS - Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds - Part II
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2. MECHANISM(S) OF ACTION* - Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds - Part II
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متن کامل3. ACUTE, SUBCHRONIC, AND CHRONIC TOXICITY - Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds - Part II
3.1. SCOPE AND LIMITATIONS The acute, subchronic, and chronic toxicology of the chlorinated dioxins, dibenzofurans, biphenyls, and related compounds have been reviewed extensively in recent years. This chapter summarizes knowledge on the toxicology of tetrachlorodibenzo-p-dioxin (TCDD), but also includes references to other dioxin-like compounds when relevant data are available. Included are se...
متن کامل3. EVALUATING ATMOSPHERIC RELEASES OF DIOXIN-LIKE COMPOUNDS FROM COMBUSTION SOURCES - Part I, Volume 3 of Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds
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متن کاملIs 2,3,7,8-TCDD (dioxin) a carcinogen for humans?
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has suddenly become the focal point of controversy over the relationship of chemical waste to human health. Specific concern exists regarding its potential association with human malignancy. Subcellular, cellular, and whole-animal experiments suggest that TCDD exerts much of its activity by inducing enzymes that protect the intact organism from the ass...
متن کاملExocrine pancreatic pathology in female Harlan Sprague-Dawley rats after chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds.
We evaluated the effect of chronic exposure to dioxin and dioxin-like compounds on the pancreas in female Harlan Sprague-Dawley rats. This investigation represents part of an ongoing National Toxicology Program initiative to determine the relative potency of chronic toxicity and carcinogenicity of polychlorinated dioxins, furans, and biphenyls. Animals were treated by gavage for up to 2 years w...
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